一次致命的多虑平过量服用。

A fatal dothiepin overdose.

作者信息

Cirimele V, Kintz P, Tracqui A, Mangin P

机构信息

Institut de Médecine Légale, Strasbourg, France.

出版信息

Forensic Sci Int. 1995 Dec 29;76(3):205-9. doi: 10.1016/0379-0738(95)01823-9.

DOI:10.1016/0379-0738(95)01823-9

PMID:8566923

Abstract

High pressure liquid chromatography coupled to photodiode array detector and capillary gas chromatography coupled to mass spectrometry were employed to quantify dothiepin in biological fluids, tissues and hair in a death attributed to oral dothiepin (Prothiaden) ingestion. The blood concentration of dothiepin was 5.75 mg/l. Hair analysis clearly indicated a chronic antidepressant exposure, with a dothiepin concentration of 1.89 ng/mg hair. Results are discussed in the light of the existing literature.

摘要

采用高压液相色谱-光电二极管阵列检测器联用技术以及毛细管气相色谱-质谱联用技术，对一例因口服多塞平（普罗替林）致死案例中的生物体液、组织及毛发中的多塞平进行定量分析。多塞平的血液浓度为5.75毫克/升。毛发分析明确显示存在慢性抗抑郁药暴露情况，毛发中的多塞平浓度为1.89纳克/毫克。结合现有文献对结果进行了讨论。