Cirimele V, Kintz P, Tracqui A, Mangin P
Institut de Médecine Légale, Strasbourg, France.
Forensic Sci Int. 1995 Dec 29;76(3):205-9. doi: 10.1016/0379-0738(95)01823-9.
High pressure liquid chromatography coupled to photodiode array detector and capillary gas chromatography coupled to mass spectrometry were employed to quantify dothiepin in biological fluids, tissues and hair in a death attributed to oral dothiepin (Prothiaden) ingestion. The blood concentration of dothiepin was 5.75 mg/l. Hair analysis clearly indicated a chronic antidepressant exposure, with a dothiepin concentration of 1.89 ng/mg hair. Results are discussed in the light of the existing literature.
采用高压液相色谱-光电二极管阵列检测器联用技术以及毛细管气相色谱-质谱联用技术，对一例因口服多塞平（普罗替林）致死案例中的生物体液、组织及毛发中的多塞平进行定量分析。多塞平的血液浓度为5.75毫克/升。毛发分析明确显示存在慢性抗抑郁药暴露情况，毛发中的多塞平浓度为1.89纳克/毫克。结合现有文献对结果进行了讨论。
