Gaspar L E
Department of Radiation Oncology, Wayne State University, Detroit, Michigan, USA.
J Surg Oncol. 1998 Jan;67(1):60-70. doi: 10.1002/(sici)1096-9098(199801)67:1<60::aid-jso13>3.0.co;2-z.
Brachytherapy, the direct application of a radioactive isotope into the tumor bed, delivers a high dose to the tumor as compared to the surrounding normal tissue. Interstitial brachytherapy, the placement of the isotope into a tumor bed where no lumen exists, has been described but is utilized infrequently in clinical practice. Endobronchial brachytherapy, the placement of the source within the airway lumen, as a boost to conventional external beam radiation has not yet demonstrated improved local tumor control or overall survival as compared to external beam alone in the definitive treatment of inoperable lung cancer. In the palliative setting, brachytherapy can provide prompt relief of obstructive symptoms and hemoptysis in the majority of patients.
近距离放射治疗是将放射性同位素直接应用于肿瘤床，与周围正常组织相比，能向肿瘤提供高剂量照射。组织间近距离放射治疗是将同位素置于不存在管腔的肿瘤床内，虽已被描述，但在临床实践中很少使用。支气管内近距离放射治疗是将放射源置于气道腔内，作为对传统外照射的增强，在不可切除肺癌的根治性治疗中，与单纯外照射相比，尚未显示出改善局部肿瘤控制或总生存期。在姑息治疗中，近距离放射治疗可使大多数患者的阻塞性症状和咯血迅速缓解。
