一种使用辣椒素建立的大鼠咽炎新模型。
A new pharyngitis model using capsaicin in rats.
作者信息
Yamabe M, Hosokawa T, Taoka T, Misawa M
机构信息
Department of Research and Development, Ryukakusan Co., Ltd., Chiba, Japan.
出版信息
Gen Pharmacol. 1998 Jan;30(1):109-14. doi: 10.1016/s0306-3623(97)00084-0.
Abstract
- Application of capsaicin solution onto the rat pharyngeal mucosa caused a well-reproducible increase in vascular permeability in the pharynx. 2. Capsaicin-induced pharyngeal inflammation was unaffected by a histamine H1 blocker and non-steroidal anti-inflammatory agents, whereas dexamethasone was effective in its inhibition. 3. FK224, a dual antagonist of tachykinin NK1 and NK2 receptors, and FK888, a selective antagonist of NK1 receptor, significantly inhibited capsaicin-induced plasma exudation in the pharynx. 4. In capsaicinized animals, the application of capsaicin solution in the pharyngeal mucosa did not induce pharyngitis. 5. These results suggest that the mechanism of the capsaicin-induced pharyngitis primarily involves tachykinins.
摘要
- 将辣椒素溶液应用于大鼠咽黏膜可导致咽部血管通透性出现可重复的增加。2. 组胺H1受体阻滞剂和非甾体抗炎药对辣椒素诱导的咽炎没有影响，而地塞米松可有效抑制该炎症。3. 速激肽NK1和NK2受体的双重拮抗剂FK224以及NK1受体的选择性拮抗剂FK888可显著抑制辣椒素诱导的咽部血浆渗出。4. 在经辣椒素处理的动物中，在咽黏膜应用辣椒素溶液不会诱发咽炎。5. 这些结果表明，辣椒素诱导咽炎的机制主要涉及速激肽。
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本文引用的文献
1
The antiinflammatory activity of glycyrrhetinic acid and derivatives.甘草次酸及其衍生物的抗炎活性。
J Pharm Pharmacol. 1958 Oct;10(10):613-20. doi: 10.1111/j.2042-7158.1958.tb10349.x.
2
Cold air-induced bronchoconstriction is mediated by tachykinin and kinin release in guinea pigs.冷空气诱导的支气管收缩是由豚鼠体内速激肽和激肽的释放介导的。
Eur J Pharmacol. 1996 Feb 5;296(3):291-6. doi: 10.1016/0014-2999(95)00719-9.
3
Role of tachykinins in bronchoconstriction induced by intravenous administration of bradykinin in guinea-pigs.
Eur Respir J. 1996 Apr;9(4):741-6. doi: 10.1183/09031936.96.09040741.
4
Involvement of substance P as a mediator in capsaicin-induced mouse ear oedema.
Inflamm Res. 1995 Nov;44(11):470-4. doi: 10.1007/BF01837912.
5
[Discovery and pharmacological properties of selective neurokinin-receptor antagonists, FK224 and FK888].[选择性神经激肽受体拮抗剂FK224和FK888的发现及其药理特性]
Nihon Yakurigaku Zasshi. 1995 Sep;106(3):193-204. doi: 10.1254/fpj.106.193.
6
Mechanisms and therapeutic potential of vanilloids (capsaicin-like molecules).香草酸类物质（辣椒素样分子）的作用机制及治疗潜力
Adv Pharmacol. 1993;24:123-55. doi: 10.1016/s1054-3589(08)60936-9.
7
Evans blue extravasation in rat dental pulp and oral tissues induced by electrical stimulation of the inferior alveolar nerve.
Arch Oral Biol. 1993 Oct;38(10):893-901. doi: 10.1016/0003-9969(93)90099-8.
8
Involvement of delta 1-opioid receptor antagonism in the antitussive effect of delta-opioid receptor antagonists.δ1-阿片受体拮抗作用参与δ-阿片受体拮抗剂的镇咳效应。
Eur J Pharmacol. 1994 Jan 14;251(2-3):291-4. doi: 10.1016/0014-2999(94)90411-1.
9
Plasma extravasation in the rat trachea induced by cold air is mediated by tachykinin release from sensory nerves.
Am J Respir Crit Care Med. 1995 Apr;151(4):1011-7. doi: 10.1164/ajrccm/151.4.1011.
10
Cigarette smoke-induced bronchoconstriction: cholinergic mechanisms, tachykinins, and cyclooxygenase products.
J Appl Physiol (1985). 1995 Jun;78(6):2260-6. doi: 10.1152/jappl.1995.78.6.2260.
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