Mitani K, Furiya Y, Uchihara T, Ishii K, Yamanouchi H, Mizusawa H, Mori H
Department of Neurology, Tokyo Metropolitan Institute of Gerontology, Japan.
J Neurol. 1998 Jan;245(1):44-6. doi: 10.1007/s004150050173.
Using a sensitive sandwich enzyme-linked immunosorbent assay (ELISA) method, we measured the concentration of total tau protein in the cerebrospinal fluid (CSF) from nine patients with corticobasal degeneration (CBD) in comparison with 12 normal control subjects in order to assess its diagnostic value. The CSF concentration of tau in patients with CBD (0.69, 0.20 ng/ml; mean, SD) was higher than that in, the normal controls (0.48, 0.14 ng/ml, P = 0.0076 unpaired t test). This increase in CBD patients may reflect widespread tau pathology in CBD, but should be interpreted with reserve as an aid to diagnosis.
我们采用灵敏的夹心酶联免疫吸附测定（ELISA）方法，检测了9例皮质基底节变性（CBD）患者脑脊液（CSF）中总tau蛋白的浓度，并与12名正常对照者进行比较，以评估其诊断价值。CBD患者脑脊液中tau蛋白浓度（0.69，0.20纳克/毫升；均值，标准差）高于正常对照者（0.48，0.14纳克/毫升，非配对t检验，P = 0.0076）。CBD患者中这种升高可能反映了CBD中广泛的tau病理改变，但作为诊断辅助手段时应谨慎解读。
