Langton C M, Whitehead M A, Langton D K, Langley G
Department of Medical Physics, University of Hull, U.K.
Med Eng Phys. 1997 Oct;19(7):599-604. doi: 10.1016/s1350-4533(97)00027-1.
A novel method for the development of a user-defined structural model simulating cancellous bone of the human calcaneus is described using stereolithography (SL). The digital image of a cancellous bone section was modified by skeletonisation and dilation to produce a structural model of uniform wall thickness, determined by the resolution of the stereolithography system. Six SL models were produced using the same data file. The SL models were assessed using the McCue CUBAclinical ultrasound bone densitometer. The broadband ultrasound attenuation (BUA) and velocity (VOS) values obtained were commensurate with the commercial phantom provided with the CUBAclinical system. The intra- and inter-sample variability for the six SL models were similar at 5% for BUA and 2.5% for VOS. Stereolithography offers the potential to firstly, simulate perforation and thinning of cancellous bone associated with osteoporosis, and secondly, to evaluate the dependence of ultrasonic and mechanical parameters upon cancellous bone structure.
描述了一种使用立体光刻（SL）开发模拟人跟骨松质骨的用户定义结构模型的新方法。通过骨架化和膨胀对松质骨切片的数字图像进行修改，以生成壁厚均匀的结构模型，壁厚由立体光刻系统的分辨率决定。使用相同的数据文件制作了六个SL模型。使用McCue CUBAclinical超声骨密度仪对SL模型进行评估。获得的宽带超声衰减（BUA）和速度（VOS）值与CUBAclinical系统提供的商业体模相当。六个SL模型的样本内和样本间变异性相似，BUA为5%，VOS为2.5%。立体光刻首先提供了模拟与骨质疏松症相关的松质骨穿孔和变薄的潜力，其次提供了评估超声和力学参数对松质骨结构的依赖性的潜力。
