Lee C J, Hsu H W, Chang Y L
Department of Chemical Engineering, National Tsing Hua University, HsinChu, Taiwan.
Med Eng Phys. 1997 Oct;19(7):658-67. doi: 10.1016/s1350-4533(96)00040-9.
The application of high clearance haemodialysis (HD) for removal of small molecules of waste metabolites, has been practised for many years. Haemoperfusion (HP) is capable of effective removal of middle and protein-bound molecules. The combined HD/HP system is thought to give a more effective treatment for patients of renal failure or drug intoxication. This paper discusses the performance characteristics of removal of toxic substances (e.g. paraquat and creatinine), using the combined HD/HP recycled system in two different arrangements (HD-HP and HP-HD). The results demonstrate that for most favourable adsorbing solutes, the HD-HP arrangement gives higher performance whereas, HP-HD arrangement is more suitable and gives more effective detoxication characteristics for unfavourable adsorbing solutes.
高清除率血液透析（HD）用于清除小分子废物代谢产物已应用多年。血液灌流（HP）能够有效清除中分子和蛋白结合分子。HD/HP联合系统被认为对肾衰竭或药物中毒患者能提供更有效的治疗。本文讨论了使用HD/HP循环联合系统的两种不同配置（HD-HP和HP-HD）清除有毒物质（如百草枯和肌酐）的性能特征。结果表明，对于大多数有利吸附的溶质，HD-HP配置性能更高，而对于不利吸附的溶质，HP-HD配置更合适且具有更有效的解毒特性。
