Rubtsov A M, Batrukova M A
Department of Biochemistry, School of Biology, Lomonosov Moscow State University, Russia.
Biochemistry (Mosc). 1997 Sep;62(9):933-45.
Recent data on characteristics of the structure, function, and regulation of sarcoplasmic reticulum Ca-release channels (ryanodine receptors) from various types of muscles are summarized. The history of identification and purification of Ca-release channels, the properties of isoforms expressed in various tissues, their electric characteristics, and regulation by endogenous and exogenous compounds are described. The phosphorylation of Ca-release channels by protein kinases and their interaction with various intracellular regulatory proteins are discussed. The proposed mechanisms of excitation-contraction coupling and the role of the Ca-release channels in this process are analyzed.
总结了来自各种类型肌肉的肌浆网钙释放通道（兰尼碱受体）的结构、功能和调节特性的最新数据。描述了钙释放通道的鉴定和纯化历史、在各种组织中表达的同工型的特性、它们的电学特性以及内源性和外源性化合物对其的调节。讨论了蛋白激酶对钙释放通道的磷酸化作用及其与各种细胞内调节蛋白的相互作用。分析了提出的兴奋-收缩偶联机制以及钙释放通道在此过程中的作用。
