Bakeeva L E, Tsiplenkova V G
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Biochemistry (Mosc). 1997 Sep;62(9):989-1002.
Endomyocardial left ventricular biopsy material from patients with chronic alcoholism exhibits structural alterations of the mitochondrial reticulum in alcohol cardiomyopathy. The progress of gradually developing structural changes depends on the stage of the disease. The early stage of the disease is characterized by spatial reorganization of the mitochondrial reticulum: intermitochondrial junctions disappear and mitochondria form separate clusters uniformly distributed within a muscle cell. Subsequently, in the second and third stages of chronic disease, destructive irreversible changes in the ultrastructural organization of mitochondria develop. Megamitochondria and septate mitochondria appear. A third additional compartment containing granules forms in mitochondria. Many lipofuscin granules appear due to the accumulation of lipids in mitochondria. Structural changes of the mitochondrial reticulum are considered as a compensatory adaptive reaction of the cardiomyocyte mitochondrial system in response to altered myocardial function in alcohol cardiomyopathy, including abnormalities in the cardiac rhythm and ventricular conductance.
慢性酒精中毒患者的左心室心内膜活检材料显示，酒精性心肌病中线粒体网状结构存在结构改变。逐渐发展的结构变化进程取决于疾病阶段。疾病早期的特征是线粒体网状结构的空间重组：线粒体间连接消失，线粒体形成单独的簇，均匀分布在肌细胞内。随后，在慢性疾病的第二和第三阶段，线粒体超微结构组织出现破坏性的不可逆变化。出现巨型线粒体和分隔线粒体。线粒体中形成了第三个含有颗粒的额外区室。由于线粒体中脂质的积累，出现了许多脂褐素颗粒。线粒体网状结构的结构变化被认为是心肌细胞线粒体系统对酒精性心肌病中心肌功能改变（包括心律失常和心室传导异常）的一种代偿性适应性反应。
