Lin R, Hill R J, Priess J R
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Howard Hughes Medical Institute, Seattle, Washington 98109, USA.
Cell. 1998 Jan 23;92(2):229-39. doi: 10.1016/s0092-8674(00)80917-4.
Blastomeres in C. elegans embryos execute lineage programs wherein the fate of a cell is correlated reproducibly with the division sequence by which that cell is born. We provide evidence that the pop-1 gene functions to link anterior-posterior cell divisions with cell fate decisions. Each anterior cell resulting from an anterior-posterior division appears to have a higher level of nuclear POP-1 protein than does its posterior sister. Genes in the C. elegans Wnt pathway are required for this inequality in POP-1 levels. We show that loss of pop-1(+) activity leads to several types of anterior cells adopting the fates of their posterior sisters. These results suggest a mechanism for the invariance of blastomere lineages.
秀丽隐杆线虫胚胎中的卵裂球执行谱系程序，其中细胞的命运与该细胞产生的分裂序列可重复地相关联。我们提供的证据表明，pop-1基因的功能是将前后细胞分裂与细胞命运决定联系起来。每次前后分裂产生的每个前体细胞似乎比其后部姐妹细胞具有更高水平的核POP-1蛋白。秀丽隐杆线虫Wnt信号通路中的基因是POP-1水平这种不平等所必需的。我们表明，pop-1(+)活性的丧失导致几种类型的前体细胞采用其后部姐妹细胞的命运。这些结果提示了一种卵裂球谱系不变性的机制。
