Boyer G S, Benevolenskaya L I, Templin D W, Erdesz S, Bowler A, Alexeeva L I, Goring W P, Krylov M Y, Mylov N M
Alaska Area Native Health Service, Anchorage, USA.
J Rheumatol. 1998 Jan;25(1):23-9.
To compare the prevalence of rheumatoid arthritis (RA) in related, but geographically separate, indigenous circumpolar populations.
Cases were identified by community survey in Russia and by examination of cases located through arthritis registries, a computerized patient information database, and query of local health care providers in Alaska. All possible cases were verified by examination and application of the American College of Rheumatology 1987 criteria.
The prevalence rates of RA (age standardized to US population of 1980) varied from 0.62% in the Alaskan Yupik to 1.78% in the Alaskan Inupiat. The Russian Chukchi rate was 0.73% and that of the Siberian Eskimo was 1.42%.
The Alaskan Yupik Eskimo and Chukchi natives had prevalence rates of RA within the usual range of North American Caucasian groups, in contrast to the Russian Siberian Eskimo and the Alaskan Inupiat Eskimo of the Barrow region, whose high rates approached those of unrelated North American native groups living in very different environments. The Alaskan Inupiat rate was significantly higher than that of the Alaskan Yupik (OR = 2.51, 95% CI 1.25-5.07; p = 0.013), but statistical inferences are limited in the Russian study populations by the small case numbers. The high prevalence rates probably have a genetic basis, although an environmental influence cannot be excluded.
比较在地理上相互分隔但有亲缘关系的北极圈原住民人群中类风湿性关节炎（RA）的患病率。
在俄罗斯通过社区调查来确定病例，并通过关节炎登记处、计算机化患者信息数据库以及向阿拉斯加当地医疗服务提供者查询来找出病例。所有可能的病例均通过检查并应用美国风湿病学会1987年标准进行核实。
RA的患病率（年龄标准化为1980年美国人口）在阿拉斯加尤皮克族中为0.62%，在阿拉斯加因纽皮特族中为1.78%。俄罗斯楚科奇族的患病率为0.73%，西伯利亚爱斯基摩族为1.42%。
阿拉斯加尤皮克爱斯基摩人和楚科奇原住民的RA患病率处于北美白种人群的常见范围内，这与俄罗斯西伯利亚爱斯基摩人和巴罗地区的阿拉斯加因纽皮特爱斯基摩人形成对比，后者的高患病率接近生活在非常不同环境中的无亲缘关系北美原住民群体。阿拉斯加因纽皮特族的患病率显著高于阿拉斯加尤皮克族（OR = 2.51，95% CI 1.25 - 5.07；p = 0.013），但在俄罗斯研究人群中，由于病例数量少，统计推断受到限制。高患病率可能有遗传基础，尽管不能排除环境影响。
