Takahashi M, Yamamoto Y, Hatori S, Shiozawa M, Suzuki M, Rino Y, Amano T, Imada T
First Department of Surgery, Yokohama City University, School of Medicine, Japan.
Oncol Rep. 1998 Jan-Feb;5(1):53-6.
Through the use of STKM-1 human stomach cancer cells, we investigated the enhancement of the anti-tumor effect and the apoptosis induction of the CDDP and caffeine combination. Even when the concentration of CDDP was low, CDDP significantly decreased the proliferation of STKM-1 human stomach cancer cells, thus confirming the synergistic effect of the CDDP and caffeine group. The apoptotic labeling index of the CDDP plus caffeine combination was significantly higher than that of the CDDP group. In conclusion, caffeine enhanced the effect of CDDP by not only inhibiting DNA repairs but also inducing apoptosis.
通过使用STKM - 1人胃癌细胞，我们研究了顺铂（CDDP）与咖啡因联合使用时抗肿瘤作用的增强及凋亡诱导情况。即使顺铂浓度较低时，它也能显著降低STKM - 1人胃癌细胞的增殖，从而证实了顺铂与咖啡因组的协同作用。顺铂加咖啡因联合组的凋亡标记指数显著高于顺铂组。总之，咖啡因不仅通过抑制DNA修复，还通过诱导凋亡来增强顺铂的作用。
