Takahashi M, Yanoma S, Yamamoto Y, Rino Y, Amano T, Imada T
First Department of Surgery, Yokohama City University, School of Medicine, Japan.
Anticancer Res. 1998 Nov-Dec;18(6A):4399-401.
This study was conducted to clarify the enhancement of the anti-tumor effect of CDDP by caffeine using a tumor-bearing peritoneal disseminated metastasis model in vivo. To evaluate the combined effect of CDDP and caffeine on the survival in vivo, nude mice bearing STKM-1 gastric cancer cells were administered CDDP alone, caffeine alone, or in both combination intraperitoneally. Treatment was started from 8 days after tumor inoculation. The combination of CDDP and caffeine more markedly prolonged the survival time than CDDP alone or caffeine alone. In conclusion, the results of the present in vivo study suggest that clinical application of caffeine in combination with CDDP might be effective against peritoneal disseminated metastasis in gastric cancer patients.
本研究旨在利用体内荷瘤腹膜播散转移模型阐明咖啡因对顺铂（CDDP）抗肿瘤作用的增强效果。为了评估顺铂和咖啡因联合使用对体内生存的影响，将携带STKM-1胃癌细胞的裸鼠分别腹腔注射单独的顺铂、单独的咖啡因或两者联合使用。在肿瘤接种后8天开始治疗。顺铂和咖啡因联合使用比单独使用顺铂或单独使用咖啡因更显著地延长了生存时间。总之，本体内研究结果表明，咖啡因与顺铂联合临床应用可能对胃癌患者的腹膜播散转移有效。
