Gardiner S M, Tomlinson D R, Bennett T
Med Biol. 1976 Jun;54(3):193-202.
The effects of Vinca alkaloids on the vas deferens have been examined after in vitro and in vivo administration. In the organ bath, vinblastine (1 X 10-4M for 4 hr) caused an increase in sensitivity to noradrenaline and biochemical, histochemical and ulstrastructural signs of noradrenaline depletion from the nerves supplying the outer longitudinal muscle layer. After intravenous injection of Vinca alkaloids the nerve fibres seemed less affected. It is concluded that the apparent resistance to the drugs in vivo is largely due to low tissue perfusion.
已在体外和体内给药后研究了长春花生物碱对输精管的作用。在器官浴中，长春碱（1×10⁻⁴M，作用4小时）使对外源性去甲肾上腺素的敏感性增加，并导致供应外纵肌层的神经中去甲肾上腺素耗竭的生化、组织化学和超微结构迹象。静脉注射长春花生物碱后，神经纤维似乎受影响较小。得出的结论是，体内对这些药物的明显抗性很大程度上是由于组织灌注不足。
