Pankov I U, Pozdniakov V I, Tumanian V G
Mol Biol (Mosk). 1976 Mar-Apr;10(2):423-36.
An analysis of primary structures for local similarities has been performed for a number of protein hormones. The statistical MacLachlan's technique and three matrices of amino acids similarities: in respect to the genetic code (M1), physico-chemical properties (M2), interchangeability of amino acids in homologous proteins (M3) have been used. When comparing prolactin and growth hormones, four zones of high structural similarity have been found. Comparison of beta-subunits of interstitial-cell and thyroid-stimulating hormones has shown two zones of high similarity. Using M3 matrice, non-homogeneity of the self local similarity of structure has been shown for prolactin, growth hormone, beta-lipotropin, proinsulin and parathormone. For the latter three hormones, the high evolutionary conservative regions coincide with the active sites of structure. It is suggested that such regions in the structures of prolactin and growth hormone also provide the active function.
对多种蛋白质激素的一级结构进行了局部相似性分析。采用了统计性的麦克拉克伦技术以及三种氨基酸相似性矩阵：基于遗传密码（M1）、物理化学性质（M2）、同源蛋白质中氨基酸的可互换性（M3）。在比较催乳素和生长激素时，发现了四个高度结构相似的区域。对促间质细胞激素和促甲状腺激素的β亚基进行比较，显示出两个高度相似的区域。使用M3矩阵，已表明催乳素、生长激素、β-促脂素、胰岛素原和甲状旁腺激素的自身局部结构相似性存在非均一性。对于后三种激素，高度进化保守区域与结构的活性位点重合。有人提出，催乳素和生长激素结构中的此类区域也具有活性功能。
