Forones N M, Tanaka M, Machado D, Falcão J B, Giovanoni M
Disciplina de Gastroenterologia, Escola Paulista de Medicina, Universidade Federal de São Paulo-UNIFESP-EPM.
Arq Gastroenterol. 1997 Jan-Mar;34(1):3-6.
The aim of this study was to evaluate the serum carcinoembryonic antigen levels in the diagnosis and in monitoring colorectal cancer patients at different Dukes' stage. Carcinoembryonic antigen serum levels were measured by Elisa using Sorine Biomedica kit (normal value: 5 ng/ml) in 240 colorectal adenocarcinoma. In the diagnosis, carcinoembryonic antigen levels were measured in 109 patients, in 42% of them, the carcinoembryonic antigen levels were elevated. The carcinoembryonic antigen levels were also evaluated in 309 serum from treated colorectal cancer patients. Fifty-nine percent of the serum of the patients with recurrence disease had elevated carcinoembryonic antigen levels and 41% of the serum of patients without recurrence also have elevated serum carcinoembryonic antigen levels. Ninety percent of the serum from treated patients without recurrence have normal serum carcinoembryonic antigen levels. We concluded that the sensitivity of carcinoembryonic antigen is lower in the diagnosis as described in others studies, mostly in patients with better prognosis. In the monitoring, patients with normal serum carcinoembryonic antigen levels, probably have no recurrence of the disease. In the other hand, patients with elevated serum carcinoembryonic antigen levels can have or not relapsed disease.
本研究的目的是评估血清癌胚抗原水平在不同杜克分期的结直肠癌患者诊断及病情监测中的作用。采用索林生物医学公司的试剂盒，通过酶联免疫吸附测定法（ELISA）检测了240例结直肠癌患者的癌胚抗原血清水平（正常值：5 ng/ml）。在诊断方面，对109例患者进行了癌胚抗原水平检测，其中42%的患者癌胚抗原水平升高。还对309例接受治疗的结直肠癌患者的血清进行了癌胚抗原水平评估。复发患者血清中59%的癌胚抗原水平升高，未复发患者血清中41%的癌胚抗原水平也升高。90%未复发的接受治疗患者的血清癌胚抗原水平正常。我们得出结论，如其他研究所述，癌胚抗原在诊断中的敏感性较低，主要是在预后较好的患者中。在病情监测中，血清癌胚抗原水平正常的患者可能没有疾病复发。另一方面，血清癌胚抗原水平升高的患者可能有疾病复发，也可能没有。
