Forones N M, Tanaka M, Machado D
Setor de Oncologia, Escola Paulista de Medicina, Universidade Federal de São Paulo-UNIFESP-EPM.
Arq Gastroenterol. 1998 Apr-Jun;35(2):100-3.
Carcinoembryonic antigen has been used to monitor colorectal cancer treated patients, elevated carcinoembryonic antigen allows to predict recurrence however some serum levels is not ever a sign of disease. In a last paper 21% of the colorectal cancer patients treated surgically had not recurrent disease. The aim of the study was to follow these patients for at least one year. Thirty two patients with elevated carcinoembryonic antigen serum levels were studied. Five were excluded and 27 were followed with chest RX, computadorized tomography and colonoscopy. Carcinoembryonic antigen serum levels were measured by ELISA using Sorine Biomedica kit (normal value: 5 ng/ml). Eleven patients (41%) developed recurrence, seven had liver metastasis. The mean time among the elevated serum carcinoembryonic antigen and the recurrence was 6.6 months. The recurrence was not observed in 18 patients, the carcinoembryonic antigen serum levels become normal in eight and in the eight others the carcinoembryonic antigen serum levels persisted elevated. Carcinoembryonic antigen serum levels can be elevated before the diagnosis of recurrence, mostly in liver metastasis, however, a number of patients with elevated carcinoembryonic antigen serum levels do not have a known cause.
癌胚抗原已被用于监测接受治疗的结直肠癌患者，癌胚抗原升高有助于预测复发，然而一些血清水平升高并非疾病的标志。在最近一篇论文中，21%接受手术治疗的结直肠癌患者没有复发疾病。本研究的目的是对这些患者进行至少一年的随访。对32例癌胚抗原血清水平升高的患者进行了研究。5例被排除，27例接受胸部X线、计算机断层扫描和结肠镜检查。使用索林生物医学试剂盒通过ELISA法测定癌胚抗原血清水平（正常值：5 ng/ml）。11例患者（41%）出现复发，7例有肝转移。血清癌胚抗原升高至复发的平均时间为6.6个月。18例患者未观察到复发，8例患者的癌胚抗原血清水平恢复正常，另外8例患者的癌胚抗原血清水平持续升高。癌胚抗原血清水平可能在复发诊断前升高，主要发生在肝转移时，然而，一些癌胚抗原血清水平升高的患者病因不明。
