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[胃肠病患者住院导致的蛋白质能量营养不良]

[Protein-energy malnutrition as a consequence of the hospitalization of gastroenterologic patients].

作者信息

Papini-Berto S J, Dichi J B, Dichi I, Victória C R, Burini R C

机构信息

Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista-UNESP.

出版信息

Arq Gastroenterol. 1997 Jan-Mar;34(1):13-21.

PMID:9458955
Abstract

The effects of the clinical and dietetics in patient managements on the protein-energy status of hospitalized patients were retrospectively (four yr) investigated in 243 adult (49 +/- 16 yr), male (168) and female (75) patients suffering from chronic liver diseases (42%), intestinal diseases with diarrhea (14%), digestive cancers (11%), chronic pancreatitis (10%), stomach and duodenum diseases (7%), acute pancreatitis (7%), primary protein-energy malnutrition (3%), esophagus diseases (3%), intestinal diseases with constipation 14 (2%) and chronic alcoholism (2%). The protein-energy nutritional status assessed by combinations of anthropometric and blood parameters showed 75% of protein energy malnutrition at the hospital entry mostly (4/5) in severe and moderate grades. The overall average of hospitalization was 20 +/- 15 days being the shortest (13 +/- 5,7 days) for esophagus diseases and the longest (28 +/- 21 days) for the intestinal diseases with diarrhea patients which also received mostly (42%) of the enteral and/or parenteral feedings followed by acute pacreatitis (41%) and digestive cancers (31%) patients. When compared to the entry the protein-energy malnutrition rate at the discharge decreased only 5% despite the increasing of 30% found on the protein-energy intake. The main improvement of the protein-energy nutritional status were attained to those patients showing protein-energy malnutrition milder degrees at the entry which belonged mostly to primary protein-energy malnutrition, acute pancreatitis and intestinal diseases with diarrhea diseases. The later two groups showed protein-energy nutritional status improvement only after the second week of hospitalization. The digestive cancers patients had their protein-energy nutritional status worsened throughout the hospitalization whereas it happened only in the first week for the intestinal diseases with diarrhea and chronic liver diseases patients, improving thereafter up to the discharge. The protein-energy nutritional status improvement found in few patients could be attributed to some complementary factors such as theirs mild degree of protein-energy malnutrition at entry and/or non-invasive propedeutics and/or enteral-parenteral feddings and/or longer hospitalization staying. The institutional causes for the unexpected lack of nutritional responses by the patients were probably the high demand for the few available beds which favour the hospitalization of the most severed patients and the university-teaching pressure for the high rotation of the available beds. Both often resulting in early discharging. In persisting the current physical area and attendance demand one could suggest an aggressive support early at the entry preceding and/or accompanying the more invasive propedeutical procedures.

摘要

对243例成年(49±16岁)患者(男性168例,女性75例)进行了为期4年的回顾性研究,这些患者患有慢性肝病(42%)、伴有腹泻的肠道疾病(14%)、消化道癌症(11%)、慢性胰腺炎(10%)、胃和十二指肠疾病(7%)、急性胰腺炎(7%)、原发性蛋白质-能量营养不良(3%)、食管疾病(3%)、伴有便秘的肠道疾病(2%)和慢性酒精中毒(2%),旨在调查临床和饮食治疗在患者管理中对住院患者蛋白质-能量状态的影响。通过人体测量和血液参数组合评估的蛋白质-能量营养状况显示,入院时75%的患者存在蛋白质-能量营养不良,大多(4/5)为重度和中度。住院总平均时间为20±15天,食管疾病患者最短(13±5.7天),伴有腹泻的肠道疾病患者最长(28±21天),这些患者也大多(42%)接受了肠内和/或肠外营养,其次是急性胰腺炎患者(41%)和消化道癌症患者(31%)。与入院时相比,出院时蛋白质-能量营养不良率仅下降了5%,尽管蛋白质-能量摄入量增加了30%。蛋白质-能量营养状况的主要改善出现在入院时蛋白质-能量营养不良程度较轻的患者中,这些患者大多属于原发性蛋白质-能量营养不良、急性胰腺炎和伴有腹泻的肠道疾病。后两组仅在住院第二周后蛋白质-能量营养状况有所改善。消化道癌症患者在整个住院期间蛋白质-能量营养状况恶化,而伴有腹泻的肠道疾病和慢性肝病患者仅在第一周出现这种情况,此后直至出院有所改善。少数患者蛋白质-能量营养状况的改善可能归因于一些补充因素,如入院时蛋白质-能量营养不良程度较轻和/或非侵入性诊断程序和/或肠内-肠外营养和/或住院时间较长。患者营养反应意外缺乏的制度性原因可能是对少数可用床位的高需求,这有利于最严重患者的住院治疗,以及大学教学对可用床位高周转率的压力。这两者往往导致提前出院。在维持当前的物理区域和就诊需求的情况下,可以建议在更具侵入性的诊断程序之前和/或伴随进行的入院早期提供积极支持。

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