通过氧电极测量确定的肿瘤氧合与氟化2-硝基咪唑SR-4554的磁共振波谱之间的关系。
The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554.
作者信息
Aboagye E O, Maxwell R J, Horsman M R, Lewis A D, Workman P, Tracy M, Griffiths J R
机构信息
CRC Department of Medical Oncology, Beatson Laboratories, Glasgow, UK.
出版信息
Br J Cancer. 1998;77(1):65-70. doi: 10.1038/bjc.1998.10.
The relationship between two methods of assessing tumour oxygenation in vivo, namely oxygen electrode measurement and magnetic resonance spectroscopy (MRS) of the fluorinated 2-nitroimidazole SR-4554, was investigated. Using three tumour models (two sites), no linear correlation was observed between 19F retention index and pO2 parameters (r < or = 0.3). Substantial retention of SR-4554 (19F retention index > 0.5) was, however, associated with low tumour pO2 (% pO2 < or = 5 mmHg = 60%). Depending on the pO2 parameters used, SR-4554 administration was shown to produce either a significant or a non-significant increase in tumour oxygenation. We conclude that measurement of SR-4554-related compound(s) by 19F-MRS has the potential to detect clinically relevant levels of tumour hypoxia.
研究了体内评估肿瘤氧合的两种方法之间的关系，即氧电极测量和氟化2-硝基咪唑SR-4554的磁共振波谱（MRS）。使用三种肿瘤模型（两个部位），未观察到19F保留指数与pO2参数之间存在线性相关性（r≤0.3）。然而，SR-4554的大量保留（19F保留指数>0.5）与低肿瘤pO2（%pO2≤5 mmHg=60%）相关。根据所使用的pO2参数，显示给予SR-4554可使肿瘤氧合显著增加或无显著增加。我们得出结论，通过19F-MRS测量与SR-4554相关的化合物有潜力检测临床上相关的肿瘤缺氧水平。
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