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[暴露于抗氧化剂期间心肌细胞的增殖、分化和死亡]

[The proliferation, differentiation and death of cardiomyocytes during exposure to an antioxidant].

作者信息

Ibragimova I F, Danilov R K, Zagidullin Sh Z

出版信息

Morfologiia. 1997;112(5):50-4.

PMID:9460680
Abstract

Influence of ionolum--vitamin E analog on differentiation, proliferative activity, cell death and content of products of lipid peroxide oxidation in chick embryo cardiac muscular tissue was studied in normal embryogenesis and in myocardial hypertrophy development. Administration of antioxidant to chick embryo was shown to result in intensified and prolonged proliferation, delayed differentiation and reduced cardiomyocyte death index both in normal histogenesis and in myocardial hypertrophy development. Use of the drug leads to viability increase in embryos exposed to extreme environmental factor action.

摘要

研究了离子发光-维生素E类似物对正常胚胎发育和心肌肥大发展过程中鸡胚心肌组织分化、增殖活性、细胞死亡及脂质过氧化产物含量的影响。结果表明,在正常组织发生和心肌肥大发展过程中,给鸡胚施用抗氧化剂均导致增殖增强和延长、分化延迟以及心肌细胞死亡指数降低。使用该药物可提高暴露于极端环境因素作用下的胚胎的活力。

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