Erker J C, Desai S M, Leary T P, Chalmers M L, Montes C C, Mushahwar I K
Virus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, IL 60064, USA.
J Gen Virol. 1998 Jan;79 ( Pt 1):41-5. doi: 10.1099/0022-1317-79-1-41.
The recent isolation of GB viruses A and B from GB agent infected tamarins and their lack of involvement in human hepatitis has sparked interest in the origin of these viruses. Several healthy non-human primate species have been shown to harbour sequences 52-79% identical to the GBV-A 5' nontranslated region. In this paper we report the near genome length sequence of GBV-Amx 70047 and GBV-Atri 1122. These sequences support previous observations about the genomic organization of GBV-A and provide insight into the genomic variability within this virus genus. Although the GBV-A variant polyproteins possess many motifs conserved between other members of the Flaviviridae, they do not encode a basic core-like protein. Amino acid sequence comparisons and phylogenetic analysis demonstrate variability within the GBV-A genus similar to that observed between hepatitis C virus (HCV) types. However, genomic organization and disease association demonstrate a closer evolutionary relationship to GBV-C than to HCV.
最近从感染GB病毒的绢毛猴中分离出GB病毒A和B，且它们与人类肝炎无关，这引发了人们对这些病毒起源的兴趣。已证明几种健康的非人灵长类动物物种携带与GBV-A 5'非翻译区有52%-79%同源性的序列。在本文中，我们报告了GBV-Amx 70047和GBV-Atri 1122的近基因组长度序列。这些序列支持了先前关于GBV-A基因组组织的观察结果，并为该病毒属内的基因组变异性提供了见解。尽管GBV-A变异多聚蛋白具有黄病毒科其他成员之间保守的许多基序，但它们不编码类似核心的碱性蛋白。氨基酸序列比较和系统发育分析表明，GBV-A属内的变异性与丙型肝炎病毒（HCV）各型之间观察到的变异性相似。然而，基因组组织和疾病关联表明，与HCV相比，GBV-A与GBV-C的进化关系更密切。
