Sibley Samuel D, Lauck Michael, Bailey Adam L, Hyeroba David, Tumukunde Alex, Weny Geoffrey, Chapman Colin A, O'Connor David H, Goldberg Tony L, Friedrich Thomas C
Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
PLoS One. 2014 Jun 11;9(2):e98569. doi: 10.1371/journal.pone.0098569. eCollection 2014.
Within the Flaviviridae, the recently designated genus Pegivirus has expanded greatly due to new discoveries in bats, horses, and rodents. Here we report the discovery and characterization of three simian pegiviruses (SPgV) that resemble human pegivirus (HPgV) and infect red colobus monkeys (Procolobus tephrosceles), red-tailed guenons (Cercopithecus ascanius) and an olive baboon (Papio anubis). We have designated these viruses SPgVkrc, SPgVkrtg and SPgVkbab, reflecting their host species' common names, which include reference to their location of origin in Kibale National Park, Uganda. SPgVkrc and SPgVkrtg were detected in 47% (28/60) of red colobus and 42% (5/12) red-tailed guenons, respectively, while SPgVkbab infection was observed in 1 of 23 olive baboons tested. Infections were not associated with any apparent disease, despite the generally high viral loads observed for each variant. These viruses were monophyletic and equally divergent from HPgV and pegiviruses previously identified in chimpanzees (SPgVcpz). Overall, the high degree of conservation of genetic features among the novel SPgVs, HPgV and SPgVcpz suggests conservation of function among these closely related viruses. Our study describes the first primate pegiviruses detected in Old World monkeys, expanding the known genetic diversity and host range of pegiviruses and providing insight into the natural history of this genus.
在黄病毒科中，最近新设立的帕吉病毒属由于在蝙蝠、马和啮齿动物中的新发现而大幅扩充。在此，我们报告了三种猿猴帕吉病毒（SPgV）的发现及特征，它们与人类帕吉病毒（HPgV）相似，感染红疣猴（Procolobus tephrosceles）、赤尾长尾猴（Cercopithecus ascanius）和一只东非狒狒（Papio anubis）。我们将这些病毒命名为SPgVkrc、SPgVkrtg和SPgVkbab，这反映了其宿主物种的俗名，其中还提及了它们起源于乌干达基巴莱国家公园的地点。分别在47%（28/60）的红疣猴和42%（5/）的赤尾长尾猴中检测到SPgVkrc和SPgVkrtg，而在23只接受检测的东非狒狒中，有1只感染了SPgVkbab。尽管观察到每个变体的病毒载量普遍较高，但这些感染并未与任何明显疾病相关联。这些病毒是单系的，与HPgV以及先前在黑猩猩中鉴定出的帕吉病毒（SPgVcpz）的差异程度相同。总体而言，新型SPgV、HPgV和SPgVcpz之间遗传特征的高度保守表明这些密切相关病毒之间功能的保守性。我们的研究描述了在旧世界猴中首次检测到的灵长类帕吉病毒，扩展了已知的帕吉病毒遗传多样性和宿主范围，并为该属的自然史提供了见解。
