Pakker N G, Notermans D W, de Boer R J, Roos M T, de Wolf F, Hill A, Leonard J M, Danner S A, Miedema F, Schellekens P T
Department of Clinical Viro-Immunology, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Nat Med. 1998 Feb;4(2):208-14. doi: 10.1038/nm0298-208.
The origin of CD4+ T cells reappearing in the blood following antiretroviral therapy in human immunodeficiency virus type-1 (HIV-1) infection is still controversial. Here we show, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4+ T-cell numbers reach a plateau. The increase in CD4+ T cells following therapy most likely is a composite of initial redistribution, accompanied by a continuous slow repopulation with newly produced naive T cells.
在1型人类免疫缺陷病毒（HIV-1）感染中，抗逆转录病毒治疗后血液中重新出现的CD4+ T细胞的来源仍存在争议。在此，我们通过数学建模表明，T细胞向血液中的重新分布可以解释初始CD4+和CD8+记忆T细胞再填充之间的显著相关性，以及治疗开始3周后记忆CD4+ T细胞数量达到平稳期这一观察结果。治疗后CD4+ T细胞的增加很可能是初始重新分布的综合结果，同时伴随着新产生的幼稚T细胞的持续缓慢再填充。
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