Deep-vein thrombosis and coumarin skin necrosis associated with a factor V inhibitor with lupus-like features.
作者信息
Kamphuisen P W, Haan J, Rosekrans P C, Van Der Meer F J
机构信息
Haemostasis and Thrombosis Research Center, Department of Haematology, University Hospital Leiden, The Netherlands.
出版信息
Am J Hematol. 1998 Feb;57(2):176-8. doi: 10.1002/(sici)1096-8652(199802)57:2<176::aid-ajh14>3.0.co;2-a.
Abstract
We report a 71-year-old man who developed deep-vein thrombosis after major surgery. Coumarin skin necrosis developed after starting oral anticoagulant therapy. An inhibitor to factor V (61 Bethesda units) with lupus-like features was found as well as a low protein C level. The occurrence of these very rare findings indicates that despite profound procoagulant inhibition (factor V inhibition and anticoagulant therapy), hypercoagulation can occur.
摘要
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