[Influence of vitamins-antioxidants on antiaggregative effect of acetylsalicylic acid].

Antiaggregative effect of aspirin has been studied in white rats that were given vitamins A, E, C and P in balanced diet in doses adequate to therapeutic ones. Aspirin (15 mg/100 g of body weight) without additional vitamin dose inhibits spontaneous and ADP-induced aggregation to 50% within 3 days following its administration restricting release of thrombocytic factors 3 and 4 into plasma, maximal aggregation, maximal reaction time and aggregation rate decreasing. Antiaggregative effect of aspirin is intensified with additional vitamins administration since the 4th day: aggregation inhibition lasting 5 days is noted in a dose of 5 mg/100 g of weight; antiaggregative effect of 10 mg dose of aspirin in combination with vitamin is higher than that of aspirin in a dose of 15 mg/100 g in animals without additional vitamin administration. Vitamins intensify antiaggregative effect of aspirin, prolongate its activity, increase hypocoaguloemia due to reduced releasing of thrombocytic factors 3 and 4 into plasma. Anticoagulative effect of vitamin combination examined is insufficient, however it potentiates aspirin antiaggregative effect. It is expedient to study vitamin combination influence on treating the diseases when thrombocyte aggregative activity increase does not take effect on pathologic process. So, administration of vitamin combination studied is likely to diminish thrombocyte aggregative activity to a level needed using lower aspirin doses.