哌唑嗪用于治疗伴有心力衰竭的高血压。

Prazosin in hypertension with heart failure.

作者信息

Antani J A

出版信息

J Cardiovasc Pharmacol. 1979 Nov-Dec;1(6 Suppl):S56-62.

Abstract

Prazosin, in daily doses of 6--16 mg, was used along with furosemide and polythiazide in 11 hypertensive heart failure patients. Average supine and standing blood pressures were reduced from 180/108 and 171/106 to 130/84 and 135/86, respectively. Average heart rate decreased from 83 to 73 supine and from 84 to 75 standing. Changes in the indices of cardiac function--indlucing the ejection fraction, ejection time, and apical indices--each indicated improvement of left ventricular function. Thus prazosin along with diuretic agents may be particularly useful in the treatment simultaneously of heart failure and of elevated blood pressure with few side effects.

摘要

对11例高血压性心力衰竭患者，使用了每日剂量为6 - 16毫克的哌唑嗪，同时还使用了速尿和多噻嗪。仰卧位和站立位平均血压分别从180/108和171/106降至130/84和135/86。平均心率仰卧位从83次降至73次，站立位从84次降至75次。心功能指标的变化——包括射血分数、射血时间和心尖指标——均表明左心室功能有所改善。因此，哌唑嗪与利尿剂联合使用可能对同时治疗心力衰竭和高血压特别有用，且副作用较少。