van Meeteren N L, Brakkee J H, Helders P J, Croiset G, Gispen W H, Wiegant V M
Rudolf Magnus Institute for Neurosciences, Utrecht University, Faculty of Medicine, Department of Medical Pharmacology, The Netherlands.
Neurosci Lett. 1997 Dec 5;238(3):131-4. doi: 10.1016/s0304-3940(97)00870-7.
The relation between recovery of function following a sciatic nerve crush lesion and an individual behavioural characteristic, the locomotor activity in an open field, was investigated in rats. Ten high-active (HA) and ten low-active (LA) rats were selected from a stock of sixty male, random-bred Wistar rats, by measuring travelled distance in an open field. Subsequently, both HA and LA rats underwent an unilateral sciatic nerve crush. Recovery of motor function revealed no significant differences between both groups, whereas recovery of sensory function in HA rats was significantly more rapid than in the LA rats (P < 0.01). These observations suggest the existence of a relationship between individual behavioural characteristics, and the sensory recovery of nerve function following crush lesion in rats.
在大鼠中研究了坐骨神经挤压损伤后功能恢复与个体行为特征（旷场中的运动活动）之间的关系。通过测量旷场中的行进距离，从60只雄性随机繁殖的Wistar大鼠种群中挑选出10只高活性（HA）大鼠和10只低活性（LA）大鼠。随后，HA和LA大鼠均接受单侧坐骨神经挤压。运动功能恢复在两组之间无显著差异，而HA大鼠的感觉功能恢复明显比LA大鼠快（P < 0.01）。这些观察结果表明大鼠个体行为特征与挤压损伤后神经功能的感觉恢复之间存在关联。
