Northcutt R G, Barlow L A
Scripps Institute of Oceanography, Dept of Neurosciences, University of California, San Diego, La Jolla 92093, USA.
Trends Neurosci. 1998 Jan;21(1):38-43. doi: 10.1016/s0166-2236(97)01146-6.
Until recently, the predominant model of taste-bud development was one of neural induction: ingrowing sensory fibers were thought to induce taste-bud differentiation late in embryonic development. Recent experimental studies, however, show that the development of taste buds is independent of their innervation. In amphibian embryos, the ability to generate taste buds is an intrinsic feature of the oropharyngeal epithelium long before the region becomes innervated. These studies indicate that patterning of the oropharyngeal epithelium occurs during gastrulation, and suggest that taste buds or their progenitors play the dominant role in the development of their own innervation.
直到最近，味蕾发育的主流模型还是神经诱导模型：在胚胎发育后期，向内生长的感觉纤维被认为会诱导味蕾分化。然而，最近的实验研究表明，味蕾的发育与其神经支配无关。在两栖类胚胎中，早在口咽上皮区域接受神经支配之前，产生味蕾的能力就是该上皮的一个固有特征。这些研究表明，口咽上皮的模式形成发生在原肠胚形成期，并且提示味蕾或其祖细胞在自身神经支配的发育中起主导作用。
