Ecole Normale Superieure, Institut de Biologie, 75005 Paris, France.
Semin Cell Dev Biol. 2013 Mar;24(3):200-9. doi: 10.1016/j.semcdb.2012.11.002. Epub 2012 Nov 24.
Taste buds are found in a distributed array on the tongue surface, and are innervated by cranial nerves that convey taste information to the brain. For nearly a century, taste buds were thought to be induced by nerves late in embryonic development. However, this view has shifted dramatically. A host of studies now indicate that taste bud development is initiated and proceeds via processes that are nerve-independent, occur long before birth, and governed by cellular and molecular mechanisms intrinsic to the developing tongue. Here we review the state of our understanding of the molecular and cellular regulation of taste bud development, incorporating important new data obtained through the use of two powerful genetic systems, mouse and zebrafish.
味蕾分布在舌面的分布式阵列中，由颅神经支配，将味觉信息传递到大脑。近一个世纪以来，人们一直认为味蕾是在胚胎发育后期由神经诱导产生的。然而，这种观点已经发生了巨大的变化。现在有大量的研究表明，味蕾的发育是由神经独立启动和进行的，发生在出生前很久，并受发育中舌头的细胞和分子机制的控制。在这里，我们回顾了我们对味觉芽发育的分子和细胞调控的理解状态，纳入了通过使用两种强大的遗传系统（小鼠和斑马鱼）获得的重要新数据。
