盲鼠海马位置细胞的空间放电
Spatial firing of hippocampal place cells in blind rats.
作者信息
Save E, Cressant A, Thinus-Blanc C, Poucet B
机构信息
Centre for Research in Cognitive Neuroscience, Centre National de la Recherche Scientifique, 13402 Marseille Cedex 20, France.
出版信息
J Neurosci. 1998 Mar 1;18(5):1818-26. doi: 10.1523/JNEUROSCI.18-05-01818.1998.
Abstract
The rat hippocampus contains cells that are characterized by location-specific firing. Previous work has shown that the angular position of hippocampal place cell firing fields is accurately controlled by the position of visual cues, suggesting that vision plays a important role in triggering place cell activity. However, a role for other types of information has also been suggested because place cell activity can be recorded while animals are moving in the darkness. In this study, we asked whether place fields can get established in rats that have never seen their environment. We studied place cell activity in early blind rats and found that these rats had place cells very similar to those recorded from sighted rats. This result suggests that early vision is not necessary for normal firing of hippocampal place cells. Dynamic, motion-related information in conjunction with stimulus recognition seems to be sufficient.
摘要
大鼠海马体包含具有位置特异性放电特征的细胞。先前的研究表明，海马体位置细胞放电场的角位置由视觉线索的位置精确控制，这表明视觉在触发位置细胞活动中起重要作用。然而，也有人提出其他类型信息的作用，因为在动物在黑暗中移动时可以记录到位置细胞活动。在本研究中，我们询问从未见过其环境的大鼠是否能建立位置场。我们研究了早期失明大鼠的位置细胞活动，发现这些大鼠的位置细胞与有视力大鼠记录到的位置细胞非常相似。这一结果表明，早期视觉对于海马体位置细胞的正常放电不是必需的。动态的、与运动相关的信息连同刺激识别似乎就足够了。
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