Král B, Krejsek J, Paráková Z, Kopecký O, Vokurková D, Derner V, Tousková M
IInd Department of Medicine, Charles University, Faculty of Medicine, Hradec Králové.
Acta Medica (Hradec Kralove). 1997;40(3):61-70.
The main aim of the present study was a search for a characteristic serum marker of inflammatory activity in the airways of asthmatics with difficult-to-control disease. Therefore, serum levels of interleukin-4 (IL-4), serum low-affinity Fc Epsilon Receptor II (sFcER II), Interferon-gamma (INF-gamma) Immunoglobulin-E (IgE), Interleukin-2 (IL-2), serum Interleukin Receptor 2 (sIL-2R) and Intercellular Adhesion Molecule-1 (sICAM-1) were measured in 2 groups of asthmatics: 1-26 patients with difficult-to-control asthma (DTCA), 2-22 asthmatics, minimally symptomatic (MSA).
No significant difference in either measured parameters between the DTCA and MSA group in peripheral blood samples was found.
The above mentioned serum markers of T- and B-cell activation as well as the serum ICAM-1 level are not sensitive enough to determine the type, activity and severity of the inflammatory process in the asthmatic airways.
本研究的主要目的是寻找难以控制的哮喘患者气道炎症活动的特征性血清标志物。因此，在两组哮喘患者中检测了白细胞介素-4（IL-4）、血清低亲和力Fcε受体II（sFcER II）、干扰素-γ（INF-γ）、免疫球蛋白E（IgE）、白细胞介素-2（IL-2）、血清白细胞介素受体2（sIL-2R）和细胞间黏附分子-1（sICAM-1）的血清水平：1-26例难以控制的哮喘（DTCA）患者，2-22例症状轻微的哮喘（MSA）患者。
在DTCA组和MSA组的外周血样本中，所测参数均无显著差异。
上述T细胞和B细胞激活的血清标志物以及血清ICAM-1水平不足以灵敏地确定哮喘气道炎症过程的类型、活动度和严重程度。
