HIV-1感染中CD4+ T细胞的快速更新：重新审视的范例 - Suppr

Rapid CD4+ T-cell turnover in HIV-1 infection: a paradigm revisited.

作者信息

Wolthers K C, Schuitemaker H, Miedema F

机构信息

Dept of Clinical Viro-Immunology, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.

出版信息

Immunol Today. 1998 Jan;19(1):44-8. doi: 10.1016/s0167-5699(97)01188-2.

DOI:10.1016/s0167-5699(97)01188-2

PMID:9465488

Abstract

摘要

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Rapid CD4+ T-cell turnover in HIV-1 infection: a paradigm revisited.HIV-1感染中CD4+ T细胞的快速更新：重新审视的范例

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[Autophagy and CD4 T lymphocyte destruction by HIV-1].[自噬与HIV-1对CD4 T淋巴细胞的破坏]

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T cell telomere length in HIV-1 infection: no evidence for increased CD4+ T cell turnover.HIV-1感染中的T细胞端粒长度：无证据表明CD4+ T细胞周转率增加。

Science. 1996 Nov 29;274(5292):1543-7. doi: 10.1126/science.274.5292.1543.

Biochemical mechanisms of HIV induced T cell apoptosis.HIV诱导T细胞凋亡的生化机制。

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The dynamics of T-lymphocyte turnover in AIDS.艾滋病中T淋巴细胞更新的动态变化。

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Psychoneuroimmunology and human immunodeficiency virus type 1 infection revisited.再探心理神经免疫学与1型人类免疫缺陷病毒感染

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Rapid CD4(+) T-cell loss induced by human immunodeficiency virus type 1(NC) in uninfected and previously infected chimpanzees.1型人类免疫缺陷病毒（NC）在未感染及先前已感染的黑猩猩中诱导的CD4(+) T细胞快速丧失

J Virol. 2001 Feb;75(3):1533-9. doi: 10.1128/JVI.75.3.1533-1539.2001.

CD4 T helper lymphocytes and antigen presenting cells in the physiopathology of AIDS.CD4辅助性T淋巴细胞与抗原呈递细胞在艾滋病发病机制中的作用

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Transient mobilization of human immunodeficiency virus (HIV)-specific CD4 T-helper cells fails to control virus rebounds during intermittent antiretroviral therapy in chronic HIV type 1 infection.在慢性1型人类免疫缺陷病毒（HIV）感染的间歇性抗逆转录病毒治疗期间，HIV特异性CD4辅助性T细胞的短暂动员未能控制病毒反弹。

J Virol. 2001 Jan;75(1):234-41. doi: 10.1128/JVI.75.1.234-241.2001.

T cell proliferation and apoptosis in HIV-1-infected lymphoid tissue: impact of highly active antiretroviral therapy.HIV-1感染的淋巴组织中的T细胞增殖与凋亡：高效抗逆转录病毒疗法的影响

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Treatment with recombinant growth hormone is associated with modest improvement in CD4 lymphocyte reconstitution in HIV-infected persons on antiretroviral therapy: results of ACTG A5174.在接受抗逆转录病毒治疗的HIV感染者中，使用重组生长激素治疗与CD4淋巴细胞重建的适度改善相关：ACTG A5174研究结果

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Age-associated deficiency in activation-induced up-regulation of telomerase activity in CD4+ T cells.年龄相关的CD4 + T细胞中激活诱导的端粒酶活性上调缺陷。

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CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease.来自CD4C/HIVNef转基因小鼠的CD4+ T细胞在体内表现出增强的激活，而在体外增殖受损，但对于严重的艾滋病样器官疾病的发展并非必需。

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Virus load correlates inversely with the expression of cytotoxic T lymphocyte activation markers in HIV-1-infected/AIDS patients showing MHC-unrestricted CTL-mediated lysis.在表现出MHC非限制性细胞毒性T淋巴细胞（CTL）介导的裂解作用的HIV-1感染/AIDS患者中，病毒载量与细胞毒性T淋巴细胞激活标志物的表达呈负相关。

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Changes in thymic function in HIV-positive patients treated with highly active antiretroviral therapy and interleukin-2.接受高效抗逆转录病毒疗法和白细胞介素-2治疗的HIV阳性患者胸腺功能的变化。

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Human immunodeficiency virus type 1 induces apoptosis in CD4(+) but not in CD8(+) T cells in ex vivo-infected human lymphoid tissue.1型人类免疫缺陷病毒在体外感染的人淋巴组织中可诱导CD4(+) T细胞凋亡，但不诱导CD8(+) T细胞凋亡。

J Virol. 2000 Sep;74(17):8077-84. doi: 10.1128/jvi.74.17.8077-8084.2000.

Effects of therapy with highly active anti-retroviral therapy (HAART) and IL-2 on CD4+ and CD8+ lymphocyte apoptosis in HIV+ patients.高效抗逆转录病毒疗法（HAART）联合白细胞介素-2治疗对HIV阳性患者CD4+和CD8+淋巴细胞凋亡的影响。

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Rapid CD4+ T-cell turnover in HIV-1 infection: a paradigm revisited.

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