乙酰水杨酸引起的胃液生化变化：适应失败？

Acetylsalicylic acid-induced biochemical changes in gastric juice: a failure of adaptation?

作者信息

Nain C K, Kaur U, Singh V, Dhawan V, Singh K

机构信息

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh.

出版信息

Indian J Gastroenterol. 1998 Jan;17(1):4-5.

PMID:9465503

Abstract

BACKGROUND

Acetylsalicyclic acid (ASA) causes gastric mucosal damage which diminishes with continued use due to adaptation.

METHODS

To determine the net effect of these processes on the gastric juice, we estimated acid, osmolality, bicarbonate concentration in nonparietal gastric juice, calcium, potassium and sodium in 18 patients (9 men; mean age 32 years, range 20-46) with irritable bowel syndrome, before and after 600 mg of ASA taken post-cibum thrice daily for 4 weeks. Osmolality was determined by an osmometer, acidity by titration, and Na+, K+ and Ca++ using a sodium-potassium-calcium analyzer; bicarbonate was derived from the two-component model of Feldman.

RESULTS

Gastric juice K+ and Na+ increased significantly from mean (SE) 14.6 (0.5) and 197.5 (16.3) to 16.7 (0.4) and 256.8 (18.1) mEq/L, respectively. The other parameters remained unchanged.

CONCLUSION

After four weeks of ASA ingestion there is a dichotomy of gastric mucosal injury and adaptation, with preservation of acid secretion but continued loss of Na+ and K+.

摘要

背景

乙酰水杨酸（ASA）会导致胃黏膜损伤，但由于适应性，持续使用时这种损伤会减轻。

方法

为确定这些过程对胃液的净效应，我们评估了18例肠易激综合征患者（9名男性；平均年龄32岁，范围20 - 46岁）在每日餐后服用600毫克ASA，持续4周前后非壁细胞胃液中的酸、渗透压、碳酸氢盐浓度、钙、钾和钠。渗透压通过渗透压计测定，酸度通过滴定法测定，钠、钾和钙使用钠 - 钾 - 钙分析仪测定；碳酸氢盐由费尔德曼的双组分模型推导得出。