Tokumitsu M, Yamaguchi S, Noda T, Numata A, Morikawa M, Miyata M, Yachiku S
Department of Urology, Asahikawa Medical College.
Nihon Hinyokika Gakkai Zasshi. 1997 Dec;88(12):1032-5. doi: 10.5980/jpnjurol1989.88.1032.
A case of MEN type I in a 64-year-old man is reported. He had undergone partial duodenectomy because of gastric ulcer and multiple duodenal polyps (gastrin secreting carcinoid). Blood examination revealed hypercalcemia, hyperPTHemia, and hyperprolactinemia. Neck US and CT showed enlargement of 4 parathyroid glands. Brain MRI revealed the microadenoma in left pituitary gland. Total parathyroidectomy with auto-transplantation in the left forearm were performed. Histological examination showed the hyperplasia of the parathyroid. Three and a half year after parathyroidectomy, there was no evidence of recurrence of gastrin secreting tumor and hyperparathyroidism, and enlargement of pituitary microadenoma. This is the first MEN type I case in Japan which have detected 3 endocrine tumors clinically with gastrin secreting duodenal carcinoid.
报告了一例64岁男性的I型多发性内分泌腺瘤病（MEN）。他因胃溃疡和多发性十二指肠息肉（分泌胃泌素的类癌）接受了部分十二指肠切除术。血液检查显示高钙血症、甲状旁腺激素水平升高和高催乳素血症。颈部超声和CT显示4个甲状旁腺肿大。脑部MRI显示左垂体微腺瘤。进行了甲状旁腺全切除术并将其自体移植到左前臂。组织学检查显示甲状旁腺增生。甲状旁腺切除术后三年半，未发现分泌胃泌素肿瘤复发、甲状旁腺功能亢进和垂体微腺瘤增大的迹象。这是日本首例临床上检测到3种内分泌肿瘤且伴有分泌胃泌素的十二指肠类癌的I型MEN病例。
