Nii S, Uno F, Yoshida M, Akatsuka K
Kawasaki College of Allied Health Professions.
Nihon Rinsho. 1998 Jan;56(1):22-8.
This review is concerned with the structure and assembly of HCMV, HHV6 and HHV7. A characteristic ultrastructural feature common to all these viruses is a distinct tegumentary coating of intracytoplasmic capsids. The tegument structure is also distinctly seen in the virions of HHV6 and HHV7. Morphologically, acquisition of the tegument was observed to have taken place in the cytoplasm. Immunoelectron microscopic studies of HCMV infected cells, however, have demonstrated the existence of a tegument protein, pp150, on the surface of intranuclear capsids as well as on capsids in the cytoplasm and in extracellular virions. In addition, another tegument protein, pp65 has been detected within the matrix of cytoplasmic and extracellular dense bodies but not in virions. The molecular mechanism of the assembly of beta herpesviruses was also discussed.
本综述关注人巨细胞病毒（HCMV）、人疱疹病毒6型（HHV6）和人疱疹病毒7型（HHV7）的结构与组装。所有这些病毒共有的一个特征性超微结构特征是胞质内衣壳有独特的被膜覆盖。在HHV6和HHV7的病毒粒子中也能清楚地看到被膜结构。从形态学上看，观察到被膜的获得发生在细胞质中。然而，对HCMV感染细胞的免疫电子显微镜研究表明，核内衣壳表面以及细胞质和细胞外病毒粒子中的衣壳上存在一种被膜蛋白pp150。此外，在细胞质和细胞外致密体的基质中检测到另一种被膜蛋白pp65，但在病毒粒子中未检测到。还讨论了β疱疹病毒组装的分子机制。
