Inoue N
Dept. Medicine, Univ. Washington.
Nihon Rinsho. 1998 Jan;56(1):50-5.
HHV-6 genes and their functions that are unique and different from those of HCMV are summarized. HHV-6 encodes a HSV-1 UL9 homolog that is an origin-binding protein (OBP) essential for HSV-1 DNA replication, although HCMV has no clear homolog. The HHV-6 OBP binds to sequences with similarity to alpha-herpesvirus replication origin that lie within a genomic segment serving as an origin in transient assays. Consensus sequence for OBP binding, protein domain analyses and a model for OBP-origin interactions are described. HHV-6 encodes an AAV-2 rep homolog. Its transcript is expressed at low mRNA levels as a spliced transcript. The gene product suppresses both transformation by H.ras and transcription by HIV-1 promoters. HHV-6 specific transactivator gene DR7 exhibits malignant transforming activity and its protein binds to p53. Studies on IE-A locus and an HCMV UL69 homolog are also discussed.
总结了HHV - 6与HCMV不同且独特的基因及其功能。HHV - 6编码一种HSV - 1 UL9同源物，它是HSV - 1 DNA复制所必需的起始结合蛋白（OBP），尽管HCMV没有明确的同源物。HHV - 6 OBP与α - 疱疹病毒复制起始位点相似的序列结合，这些序列位于用作瞬时分析起始位点的基因组片段内。描述了OBP结合的共有序列、蛋白质结构域分析以及OBP - 起始位点相互作用的模型。HHV - 6编码一种AAV - 2 rep同源物。其转录本以剪接转录本的形式在低mRNA水平表达。该基因产物既抑制H.ras介导的转化，也抑制HIV - 1启动子介导的转录。还讨论了对IE - A基因座和HCMV UL69同源物的研究。
