在八细胞阶段之前，人类雌性和雄性胚胎的生长速率相似。
Female and male human embryo growth rates are similar before the eight-cell stage.
作者信息
Fanchin R, Righini C, Olivennes F, Lejeune V, Volante M, Frydman R
机构信息
Department of Obstetrics and Gynecology and Reproductive Endocrinology, Hôpital Antoine Béclère, France.
出版信息
Am J Obstet Gynecol. 1998 Jan;178(1 Pt 1):45-9. doi: 10.1016/s0002-9378(98)70624-6.
OBJECTIVE
Our purpose was to assess the possible relationship between human embryo growth rates and sexual differentiation.
STUDY DESIGN
We analyzed 142 conceptional in vitro fertilization and embryo transfer cycles undertaken in 137 women (151 embryos transferred) in which each embryo transferred led to a gestational sac. Embryos were sorted into three groups according to the number of blastomeres assessed just before embryo transfers < or = 3, 4, and > or = 5 blastomeres.
RESULTS
Percentages of girls and boys remained roughly unaltered irrespective of the number of blastomeres observed just before embryo transfer: < or = 3 blastomeres, 45% and 55%; 4 blastomeres, 44% and 56%; and > or = 5 blastomeres, 45% and 55%, respectively (statistical power 90% at the 5% significance level).
CONCLUSIONS
This indicates that embryo growth rates before the eight-cell stage are not related to the sex of the live-born infant, thereby dissuading the use of embryo growth rates in the appraisal of sex likelihood in regular in vitro fertilization-embryo transfer.
目的
我们的目的是评估人类胚胎生长速率与性别分化之间可能存在的关系。
研究设计
我们分析了137名女性进行的142个体外受精与胚胎移植周期（共移植151个胚胎），其中每个移植胚胎均发育为妊娠囊。根据胚胎移植前评估的卵裂球数量，将胚胎分为三组：≤3个卵裂球、4个卵裂球和≥5个卵裂球。
结果
无论胚胎移植前观察到的卵裂球数量如何，女孩和男孩的比例大致保持不变：≤3个卵裂球时，分别为45%和55%；4个卵裂球时，分别为44%和56%；≥5个卵裂球时，分别为45%和55%（在5%显著性水平下统计效能为90%）。
结论
这表明八细胞期之前的胚胎生长速率与活产婴儿的性别无关，从而不建议在常规体外受精-胚胎移植中利用胚胎生长速率来评估性别可能性。
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