Karotkin E H, Kido M, Redding R, Cashore W J, Douglas W, Stern L, Oh W
Am J Obstet Gynecol. 1976 Mar 1;124(5):529-31. doi: 10.1016/0002-9378(76)90182-4.
Phenobarbital was administered to pregnant rabbits, 7 to 10 days before the delivery of their fetuses at 27 to 30 days of gestation. There were no differences in body weight or wet or dry lung weights between control animals and phenobarbital-treated pups at similar gestational ages. The phospholipid content (PLC) of the alevolar wash was lower in the phenobarbital-treated group, but there was no difference in the lung tissue PLC between the treated and control groups. Phenobarbital-treated pups had higher opening pressures and fewer lamellar bodies than the control animals. These data suggest that phenobarbital may have an inhibitory effect on surfactant production and/or release.
在妊娠27至30天的母兔分娩前7至10天，给它们施用苯巴比妥。在相似胎龄时，对照动物和经苯巴比妥处理的幼崽之间的体重、肺湿重或干重没有差异。经苯巴比妥处理的组中肺泡灌洗物的磷脂含量（PLC）较低，但处理组和对照组之间的肺组织PLC没有差异。与对照动物相比，经苯巴比妥处理的幼崽具有更高的开放压力和更少的板层小体。这些数据表明，苯巴比妥可能对表面活性剂的产生和/或释放具有抑制作用。
