瑞典农业中农药施用者的前列腺癌

Prostate cancer in pesticide applicators in Swedish agriculture.

作者信息

Dich J, Wiklund K

机构信息

Department of Cancer Epidemiology, Karolinska University Hospital, Stockholm, Sweden.

出版信息

Prostate. 1998 Feb 1;34(2):100-12. doi: 10.1002/(sici)1097-0045(19980201)34:2<100::aid-pros4>3.0.co;2-o.

DOI:10.1002/(sici)1097-0045(19980201)34:2<100::aid-pros4>3.0.co;2-o

PMID:9465941

Abstract

BACKGROUND

The use of chemicals in agriculture has been associated with elevated risks of prostate cancer. The aim of this study was to analyze prostate cancer risk in a cohort of 20,025 pesticide applicators in agriculture licensed between 1965-1976.

METHODS

The cohort was followed up in the Swedish Cancer Register from date of licence until death of December 31, 1991. The mean follow-up time was 21.3 years.

RESULTS

We found a statistically significant increased risk of prostate cancer with 401 cases observed compared to 355 expected, with a standardized incidence ratio (SIR) of 1.13 (95% confidence interval: 1.02-1.24). There were 7 cases among those born in 1935 or later, and the SIR was 2.03 (0.82-4.19). For those born earlier than 1935 the SIR was 1.12 (1.01-1.24).

CONCLUSIONS

These findings of a statistically significant increased risk of prostate cancer, together with recent results from other studies, imply a relationship between agrochemicals or other risk factors in the environment of farmers and prostate cancer.

摘要

背景

农业中化学品的使用与前列腺癌风险升高有关。本研究的目的是分析1965年至1976年间获得农业农药施用许可的20,025名施用者队列中的前列腺癌风险。

方法

该队列在瑞典癌症登记处从获得许可之日起随访至1991年12月31日死亡。平均随访时间为21.3年。

结果

我们发现前列腺癌风险在统计学上显著增加，观察到401例病例，而预期为355例，标准化发病率比（SIR）为1.13（95%置信区间：1.02 - 1.24）。1935年或之后出生的人群中有7例病例，SIR为2.03（0.82 - 4.19）。对于1935年之前出生的人群，SIR为1.12（1.01 - 1.24）。