Shaw A, Mobbs P J, Haines J F, Rao S, O'Connor M
Trafford General Hospital, Trafford Healthcare NHS Trust, Davyhulme, Manchester, UK.
Eur J Anaesthesiol. 1997 Nov;14(6):635-41. doi: 10.1046/j.1365-2346.1994.00203.x.
A prospective, randomized, double-blind, controlled study was conducted to assess the efficacy of intra-articular bupivacaine and diamorphine. Ninety-six day-case patients were allocated randomly to receive intra-articular injections of either 20 mL 0.9% saline (control, n = 35), 20 mL 0.5% plain bupivacaine (n = 31), or 20 mL 0.9% saline with 5 mg diamorphine (n = 30) prior to tourniquet release. Visual analogue scales (VAS) were completed at 1 h, 3 h (discharge) and 24 h, and supplementary analgesia noted. Intra-articular analgesics conferred a noticeable improvement in patient comfort. First, the quantity of supplementary analgesia required prior to discharge was significantly reduced (P = 0.016); second, patients reported a less disturbed night's sleep (P = 0.034).
进行了一项前瞻性、随机、双盲、对照研究，以评估关节腔内注射布比卡因和二氢吗啡的疗效。96例日间手术患者被随机分配，在松开止血带前接受关节腔内注射20毫升0.9%生理盐水（对照组，n = 35）、20毫升0.5%布比卡因原液（n = 31）或20毫升含5毫克二氢吗啡的0.9%生理盐水（n = 30）。在术后1小时、3小时（出院时）和24小时完成视觉模拟量表（VAS）评分，并记录补充镇痛情况。关节腔内注射镇痛药显著改善了患者的舒适度。首先，出院前所需的补充镇痛量显著减少（P = 0.016）；其次，患者报告夜间睡眠受干扰较少（P = 0.034）。
