Hickey J, Panicucci R, Duan Y, Dinehart K, Murphy J, Kessler J, Gottardi W
Symbollon Corporation, Framingham, MA 01702, USA.
J Pharm Pharmacol. 1997 Dec;49(12):1195-9. doi: 10.1111/j.2042-7158.1997.tb06069.x.
Horseradish peroxidase has been used to generate iodine compositions that comprised principally free molecular iodine. The concentration of free molecular iodine in these enzyme-based compositions ranged from 44 to 63% of the thiosulphate titratable iodine; this is substantially higher than the corresponding value for the povidone-iodine preparation betadine. The biocidal efficacy of these compositions was proportional to the concentration of free molecular iodine. Iodine compositions with relatively low total iodine concentrations but high levels of free molecular iodine (20-175 ppm) killed Staphylococcus aureus and spores of Bacillus subtilis more rapidly than betadine. The effects of normal saline and these enzyme-based iodine compositions on the rate of epidermal regeneration in superficial swine wounds were comparable. These results suggest that an effective germicide containing a high level of molecular iodine need not be irritating or toxic.
辣根过氧化物酶已被用于制备主要由游离分子碘组成的碘组合物。这些基于酶的组合物中游离分子碘的浓度占硫代硫酸盐可滴定碘的44%至63%；这大大高于聚维酮碘制剂碘伏的相应值。这些组合物的杀菌效力与游离分子碘的浓度成正比。总碘浓度相对较低但游离分子碘含量较高（20 - 175 ppm）的碘组合物比碘伏更快地杀死金黄色葡萄球菌和枯草芽孢杆菌的孢子。生理盐水和这些基于酶的碘组合物对猪浅表伤口表皮再生速率的影响相当。这些结果表明，一种含有高含量分子碘的有效杀菌剂不一定具有刺激性或毒性。
