Coombs R W, Speck C E, Hughes J P, Lee W, Sampoleo R, Ross S O, Dragavon J, Peterson G, Hooton T M, Collier A C, Corey L, Koutsky L, Krieger J N
Department of Laboratory Medicine, University of Washington, School of Medicine, Seattle 98195-7110, USA.
J Infect Dis. 1998 Feb;177(2):320-30. doi: 10.1086/514213.
Both qualitative and quantitative virologic measurements were compared between blood and genital compartments for 128 men infected with human immunodeficiency virus type 1 (HIV-1) to address several controversial issues concerning HIV-1 shedding in semen and to obtain further information about the distribution of virus between these two compartments. Evidence for viral compartmentalization was suggested by earlier studies that noted the poor correlation between blood and seminal virus load, phenotype, and genotype. Further support for this viral compartmentalization was based on the following observations between semen and blood: lack of association between culturability of virus in semen and viral RNA level in blood, discordant distribution of viral phenotypes, discordant viral RNA levels, a weak correlation between viral RNA level in semen and CD4 cell count in blood, differences in the biologic variability of viral RNA levels, and differences in the virus load response to antiretroviral therapy.
对128名感染1型人类免疫缺陷病毒（HIV-1）的男性的血液和生殖区进行了定性和定量病毒学测量，以解决几个关于HIV-1在精液中脱落的争议问题，并获取有关该病毒在这两个区域之间分布的更多信息。早期研究表明血液和精液病毒载量、表型和基因型之间相关性较差，提示存在病毒分区现象。精液和血液之间的以下观察结果进一步支持了这种病毒分区现象：精液中病毒的可培养性与血液中病毒RNA水平之间缺乏关联、病毒表型分布不一致、病毒RNA水平不一致、精液中病毒RNA水平与血液中CD4细胞计数之间相关性较弱、病毒RNA水平的生物学变异性存在差异以及对抗逆转录病毒疗法的病毒载量反应存在差异。
