Crîsnic I, Vinţi D, Cucuianu M
Med Interne. 1976 Jan-Mar;14(1):47-51.
Decreased platelet count and platelet adhesiveness as well as increased values of the protamine sulfate test were found in 26 patients with septic abortion (9 of them anuric). Serum fibrinogen-fibrin related antigen (FR-antigen) values, detected in 13 patients (7 of them anuric) were greatly increased although euglobulin lysis time was rather prolonged (more than 400 min). Less increased FR-antigen values were noted in 15 cirrhotic patients with enhanced fibrinolytic activity in the circulating blood (euglobulin lysis time less than 120 min). These findings suggest that an important increase of FR-antigen in serum is likely to indicate a local fibrinolytic response to an initial coagulation event. Since platelet count and adhesiveness as well as FR-antigen and protamine sulfate test were similarly changed in patients with septic abortion who developed acute renal failure and in those who did not, it seems that the above mentioned parameters are not predictive for the evolution of thrombotic deposits and for possible renal complications following an episode of disseminated intravascular coagulation.
在26例感染性流产患者（其中9例无尿）中发现血小板计数和血小板黏附性降低，硫酸鱼精蛋白试验值升高。在13例患者（其中7例无尿）中检测到的血清纤维蛋白原 - 纤维蛋白相关抗原（FR - 抗原）值大幅升高，尽管优球蛋白溶解时间相当延长（超过400分钟）。在15例循环血液中纤维蛋白溶解活性增强（优球蛋白溶解时间小于120分钟）的肝硬化患者中，FR - 抗原值升高较少。这些发现表明，血清中FR - 抗原的重要增加可能表明对初始凝血事件的局部纤维蛋白溶解反应。由于发生急性肾衰竭的感染性流产患者和未发生急性肾衰竭的患者的血小板计数和黏附性以及FR - 抗原和硫酸鱼精蛋白试验均有类似变化，因此上述参数似乎无法预测血栓形成沉积物的演变以及弥散性血管内凝血发作后可能出现的肾脏并发症。
