Lim-Bon-Siong R, Valluri S, Gordon M E, Pepose J S
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Am J Ophthalmol. 1998 Feb;125(2):169-76. doi: 10.1016/s0002-9394(99)80087-7.
To test the ProTek (Vifilcon A) therapeutic soft contact lens in the alleviation of post-photorefractive keratectomy pain, its effect on epithelial healing, and its safety.
Forty-seven consecutive eligible patients undergoing unilateral excimer laser photorefractive keratectomy for myopia were randomly assigned to receive standard postoperative care with or without the use of a ProTek soft contact lens. Patients prospectively graded a self-administered 5-point scale for pain and a 4-point scale for abnormal sensations at 4, 8, 12, 16, and 20 hours after surgery. They also recorded the type and dose of all medications taken during that time period. All patients were examined on the first and third days after surgery. The lenses were worn continuously for 3 days.
The soft contact lens group (n = 24) disclosed a statistically significant (P < .05) reduction in pain intensity and abnormal sensations that was greatest at 8, 12, 16, and 20 hours postoperatively. Compared with control patients (n = 23), the soft contact lens group showed significant decreased dependence on most pain medications after the 12th hour (P < .05) and faster epithelial healing (P = .03). However, one case of bacterial keratitis, two cases of subepithelial infiltrates, and seven cases of contact lens intolerance were present in the soft contact lens group.
The ProTek therapeutic soft contact lenses were effective in decreasing pain and other related abnormal sensations after excimer photorefractive keratectomy. They decreased dependence on pain medications and hastened epithelial healing but were not well tolerated in some patients.
测试ProTek（维氟康A）治疗性软性接触镜在减轻准分子激光原位角膜磨镶术后疼痛、对上皮愈合的影响及其安全性。
47例连续接受单侧准分子激光原位角膜磨镶术治疗近视的符合条件患者被随机分配接受标准术后护理，部分使用ProTek软性接触镜，部分不使用。患者在术后4、8、12、16和20小时前瞻性地使用5分制对自我感觉的疼痛程度和4分制对异常感觉进行评分。他们还记录了在此期间服用的所有药物的类型和剂量。所有患者在术后第一天和第三天接受检查。镜片连续佩戴3天。
软性接触镜组（n = 24）术后疼痛强度和异常感觉在统计学上有显著降低（P <.05），在术后8、12、16和20小时最为明显。与对照组患者（n = 23）相比，软性接触镜组在术后12小时后对大多数止痛药物的依赖显著降低（P <.05），上皮愈合更快（P =.03）。然而，软性接触镜组出现1例细菌性角膜炎、2例上皮下浸润和7例接触镜不耐受病例。
ProTek治疗性软性接触镜在减轻准分子激光原位角膜磨镶术后疼痛和其他相关异常感觉方面有效。它们减少了对止痛药物的依赖，加速了上皮愈合，但在一些患者中耐受性不佳。
