Cox H W, Calaf-Iturri G
Ann Trop Med Parasitol. 1976 Mar;70(1):73-9. doi: 10.1080/00034983.1976.11687097.
Eperythrozoon coccoides and Haemobartonella muris produced in mice and rats respectively, essentially the same disease, characterized by anaemia, splenomegaly and in severe cases, haemoglobinuria with death. In both infections anaemia was associated with phagocytosis of erythrocytes by monocytes of the spleen, and with the presence of cold-active haema-glutinin for trypsinized red cells (CAH). An antigen similar to the serum antigen (SA) associated with acute malaria and babesiosis was also found in the blood of the anaemic animals. One or two days later antibody to SA (ABSA) was detected and for several days thereafter, both SA and ABSA could be detected in plasma samples. Anaemia crisis with haemoglobinuria was better correlated with the appearance of ABSA than with the presence of CAH. It is suggested that CAH, and complexes of SA and ABSA could have acted as anaemia factors and were in part causal in the sequestration or haemolysis of erythrocytes during acute infection.
分别在小鼠和大鼠体内产生的球状附红细胞体和鼠血巴尔通体，引发的疾病基本相同，其特征为贫血、脾肿大，严重时出现血红蛋白尿并导致死亡。在这两种感染中，贫血都与脾脏单核细胞对红细胞的吞噬作用以及对胰蛋白酶处理过的红细胞存在冷活性血凝素（CAH）有关。在贫血动物的血液中还发现了一种与急性疟疾和巴贝斯虫病相关的血清抗原（SA）类似的抗原。一两天后检测到针对SA的抗体（ABSA），此后的几天里，血浆样本中均可检测到SA和ABSA。伴有血红蛋白尿的贫血危象与ABSA的出现比与CAH的存在相关性更强。有人提出，CAH以及SA和ABSA的复合物可能起到了贫血因子的作用，并且在急性感染期间红细胞的滞留或溶血过程中部分起到了因果作用。
