Matthews C E, Pate R R, Jackson K L, Ward D S, Macera C A, Kohl H W, Blair S N
School of Public Health, University of South Carolina, Columbia 29208, USA.
J Clin Epidemiol. 1998 Jan;51(1):29-35. doi: 10.1016/s0895-4356(97)00223-0.
This study examined the association between an exaggerated blood pressure response to treadmill exercise and the risk of developing hypertension. Subjects were healthy normotensive men (n = 5386) who had a baseline graded maximal exercise test between 1971 and 1982, and completed a mailed follow-up questionnaire. At follow-up in 1986, cases (n = 151) reported physician diagnosed hypertension and controls (n = 201) reported normotension. Those who had developed hypertension at follow-up were more likely to have had an exaggerated blood pressure response to exercise (OR = 2.4, 1.4-4.3). In multiple logistic regression analysis an exaggerated response was significantly associated (OR = 3.0, 1.5-6.1) with future hypertension after controlling for sitting systolic and diastolic blood pressure, weight change from age 21 to follow-up, entry age, family history of hypertension, body mass index, treadmill time, alcohol consumption, and years of follow-up. These results suggest that an exaggerated blood pressure response to exercise is independently associated with increased risk of future hypertension, and therefore, may be an important factor in determining hypertension risk.
本研究调查了跑步机运动时血压过度反应与患高血压风险之间的关联。研究对象为健康的血压正常男性（n = 5386），他们在1971年至1982年间进行了基线分级最大运动试验，并完成了一份邮寄的随访问卷。在1986年随访时，病例组（n = 151）报告经医生诊断患有高血压，对照组（n = 201）报告血压正常。随访时患高血压的人更有可能对运动有血压过度反应（比值比=2.4，1.4 - 4.3）。在多因素逻辑回归分析中，在控制了静息收缩压和舒张压、21岁至随访时的体重变化、入组年龄、高血压家族史、体重指数、跑步机运动时间、饮酒量和随访年限后，过度反应与未来患高血压显著相关（比值比=3.0，1.5 - 6.1）。这些结果表明，运动时血压过度反应与未来患高血压风险增加独立相关，因此，可能是决定高血压风险的一个重要因素。
