Malenchenko A F
Institute for Radiation Ecology Problems, Belorussian Academy of Sciences, Minsk.
Radiats Biol Radioecol. 1997 Nov-Dec;37(6):882-9.
The results of the increased functional asynchronism of the follicular structures of the thyroid gland in the endemic with respect to goitre regions at the intrathyroid distribution of radioactive iodine have been analysed. The unevenness of inclusion of radioiodine into the gland locus, which concentrate iodine, and the formation of higher dose effects in the microparts of the thyroid tissue altered by goitre, then the averaged values of irradiation of the whole gland inherent in the evaluation of risk of the thyroid carcinogenesis, has been shown. It is substantiated, that the increased deposit of some radionuclides and toxic microelements in the gland, altered by goitre, is the possible mechanism of promotion in the demonstration of the earlier initiated damaged genomes of follicular cells.
分析了甲状腺滤泡结构功能异步性增加在地方性甲状腺肿流行地区放射性碘甲状腺内分布方面的结果。已表明，放射性碘进入甲状腺集中碘的部位不均匀，以及在甲状腺肿改变的甲状腺组织微区形成更高剂量效应，高于甲状腺癌发生风险评估中整个腺体照射的平均值。证实甲状腺肿改变的腺体中某些放射性核素和有毒微量元素沉积增加，是促进显示滤泡细胞早期启动的受损基因组的可能机制。
