Tokarskaia Z B, Khokhriakov V F, Okladnikova N D, Beliaeva Z D, Zhuntova G V
Branch No 1 of Scientific Research Center of Institute of Biophysics, Ozyorsk, Russia.
Radiats Biol Radioecol. 1997 Nov-Dec;37(6):918-25.
It was shown on the basis of retrospective investigation of 500 workers at a nuclear enterprise (162 cases of lung cancer, 338 persons as matching control) that the interaction of external gamma-irradiation (> 2.0 Gy) and the body-burden of 239Pu (> 9.3 kBq) at lung cancer incidence in multiplicative. Combined influence of smoking and radiation factors was found dependent on smoking index (SI): it changed from additive up to multiplicative and than to antagonistic with the increase of the smoking effect. The received results could be explained on the basis of a two-mutation model of radiation carcinogenesis.
基于对一家核企业500名工人的回顾性调查（162例肺癌患者，338人作为匹配对照）显示，外部γ射线照射（>2.0 Gy）与肺部239Pu体内负荷（>9.3 kBq）对肺癌发病率的相互作用呈相乘关系。吸烟和辐射因素的联合影响取决于吸烟指数（SI）：随着吸烟效应的增加，其从相加作用变为相乘作用，再变为拮抗作用。所得结果可基于辐射致癌的双突变模型来解释。
