Wikberg M, Ulmius J, Ragnarsson G
Pharmaceutical and Analytical Research and Development, Astra Draco AB, Lund, Sweden.
Aliment Pharmacol Ther. 1997 Dec;11 Suppl 3:109-15. doi: 10.1111/j.1365-2036.1997.tb00815.x.
Topical therapy within the treatment of intestinal diseases presents realistic formulation challenges for targeted drug delivery. Some relevant oral formulation concepts are reviewed. The basic principles employed are based mainly on differences in pH and metabolic activity between the different parts of the gastrointestinal tract. A successful example of targeted drug delivery within the treatment of Crohn's disease is presented. Topical therapy for the treatment of ulcerative colitis is also discussed. Physiological variations and influence of the disease and disease status present major challenges when deciding upon a suitable formulation principle.
肠道疾病治疗中的局部治疗在靶向给药方面面临着实际的制剂挑战。本文综述了一些相关的口服制剂概念。所采用的基本原则主要基于胃肠道不同部位的pH值和代谢活性差异。文中介绍了克罗恩病治疗中靶向给药的一个成功实例。还讨论了溃疡性结肠炎治疗的局部疗法。在确定合适的制剂原则时，生理差异以及疾病和病情的影响带来了重大挑战。
