Foletta V C, Segal D H, Cohen D R
Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4068, USA.
J Leukoc Biol. 1998 Feb;63(2):139-52. doi: 10.1002/jlb.63.2.139.
The mechanisms regulating the development and function of the immune system are diverse and complicated. The signaling pathways and target genes that become activated upon cell-surface stimulation are currently being defined, and transcription factor activator protein 1 (AP-1) is proving to be an important regulator of nuclear gene expression in leukocytes. In vitro and in vivo studies have demonstrated that AP-1 expression is induced after a diverse range of stimuli and that AP-1 contributes to the regulation of a large number of genes. In this review we will examine the role of AP-1 during leukocyte activation and differentiation in the immune system.
调节免疫系统发育和功能的机制多种多样且错综复杂。目前正在确定细胞表面受到刺激后被激活的信号通路和靶基因，转录因子激活蛋白1（AP-1）已被证明是白细胞中核基因表达的重要调节因子。体外和体内研究均表明，AP-1的表达在受到多种刺激后被诱导，且AP-1有助于调控大量基因。在本综述中，我们将探讨AP-1在免疫系统中白细胞激活和分化过程中的作用。
