Dumonceau J M, Devière J, Delhaye M, Baize M, Cremer M
Department of Gastroenterology and Hepatopancreatology, Erasme University Hospital, Brussels, Belgium.
Gastrointest Endosc. 1998 Jan;47(1):8-17. doi: 10.1016/s0016-5107(98)70292-5.
Endoscopic treatment of postoperative benign bile duct strictures (BBDS) is technically challenging, and the long-term outcome after stricture dilation remains poorly defined.
Forty-eight cases of postoperative BBDS with attempted endoscopic treatment (either transient plastic stenting or definitive metal stent insertion) were reviewed.
Endoscopic stricture dilation succeeded in 47 of 48 cases (98%). No procedure-related mortality was observed; 16 (33%) procedure-related or stent-associated complications were observed during treatment. Endoscopic treatment was interrupted in five patients. Stricture relapse occurred in 6 of 6 (100%) and 7 of 36 (19%) patients after metal stent insertion and plastic stent removal, respectively (p < 0.001) (mean follow-up periods 50+/-12 and 44+/-34 months, respectively). After plastic stent removal, stricture relapses were more frequent among patients with strictures related to liver transplantation as opposed to other surgical procedures (p < 0.05); these recurrent strictures were successfully treated by repeated insertion of plastic stents on a temporary basis. At the end of follow-up, all but one patient treated with plastic stents had normal serum alkaline phosphatase values.
Metal stents proved to be inadequate for treating postoperative BBDS. Temporary insertion of a plastic stent (possibly repeated) provided long-term results equal or superior to those reported for surgical biliary drainage. Repeated insertion of plastic stents was more frequently indicated for strictures related to liver transplantation compared with other surgical procedures.
内镜治疗术后良性胆管狭窄(BBDS)在技术上具有挑战性,狭窄扩张后的长期疗效仍不明确。
回顾了48例尝试进行内镜治疗(临时放置塑料支架或置入永久性金属支架)的术后BBDS病例。
48例中有47例(98%)内镜下狭窄扩张成功。未观察到与手术相关的死亡;治疗期间观察到16例(33%)与手术相关或支架相关的并发症。5例患者中断了内镜治疗。金属支架置入后和塑料支架取出后,分别有6例(100%)和36例中的7例(19%)出现狭窄复发(p<0.001)(平均随访期分别为50±12个月和44±34个月)。塑料支架取出后,与其他外科手术相比,肝移植相关狭窄患者的狭窄复发更频繁(p<0.05);这些复发性狭窄通过临时重复置入塑料支架成功治疗。随访结束时,除1例接受塑料支架治疗的患者外,其余患者血清碱性磷酸酶值均正常。
金属支架被证明不足以治疗术后BBDS。临时置入塑料支架(可能需重复)可提供与外科胆管引流相当或更优的长期疗效。与其他外科手术相比,肝移植相关狭窄更常需要重复置入塑料支架。